RESEARCH

Our group has several focus areas:

• Analyzing transcription factor binding and miRNA data to study the regulation of transcription and post-transcriptional processing,
• Examining the genetic and epigenetic factors controlling gene expression,
• Exploring the metabolome and
• Integrating multiple omics data.

We also collaborate with investigators studying chronic obstructive pulmonary disease in the COPDGene genetic epidemiology study, substance use disorders using animal models, and early life determinants of diabetes and obesity in children.

ACTIVE GRANTS

Multi-omic Networks Associated with COPD progression in TOPMed Cohorts

Role: Multi-PI (Kechris, Banaei-Kashani, Bowler, Lange); NIH/NHLBI R01 HL152735 2020-2024

To help identify why only some smokers develop COPD, this proposal will integrate recently collected extensive molecular multi-omic profiles from three NHLBI cohorts to discover molecular networks that are important in both COPD diagnosis and progression.